1.
Indian J Biochem Biophys
;
1993 Dec; 30(6): 411-3
Article
in English
| IMSEAR
| ID: sea-27373
ABSTRACT
The possibility of using specific polyclonal antibodies for effective site specific drug targeting to malaria infected erythrocytes has been examined. For this purpose, rabbit polyclonal antiserum was raised against Plasmodium berghei infected mouse erythrocytes (IRBC) and extensively absorbed with normal erythrocytes (NRBC). Absorbed antiserum specifically recognized IRBC. F(ab')2-fragments of these antibodies were coupled to chloroquine (chq) laden liposomes. These immunoliposomes when tested in vivo significantly suppressed malarial infection in mice.
Subject(s)
Animals , Antibodies , Antibody Specificity , Chloroquine/administration & dosage , Drug Carriers , Erythrocytes/immunology , Immunoglobulin Fab Fragments , Liposomes , Malaria/blood , Mice , Mice, Inbred BALB C , Plasmodium berghei
2.
Indian J Biochem Biophys
;
1979 Dec; 16(6): 375-8
Article
in English
| IMSEAR
| ID: sea-28676